Linked Life Data

3209796

Source:http://linkedlifedata.com/resource/pubmed/id/3209796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1989-2-14
pubmed:abstractText
An investigation was undertaken into possible vagolytic effects of chloroquine. A single oral dose of chloroquine was given to healthy human volunteers and its influence on vagally mediated heart rate changes studied. Chloroquine at a dose of 600 mg significantly increased lying and standing heart rates, reduced the beat-to-beat variation of the R-R interval and reduced the heart rate changes induced by deep breathing, by the Valsalva manoeuvre and by standing. Chloroquine at a dose of 225 mg did not produce significant changes of these parameters. The effects of 600 mg chloroquine resemble those obtained with atropine and are consistent with an antimuscarinic receptor effect.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0165-1838
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
147-55
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Muscarinic antagonist action of clinical doses of chloroquine in healthy volunteers.
pubmed:affiliation
Department of Physiology, University of Zimbabwe, Mount Pleasant, Harare.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't