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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
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pubmed:dateCreated |
1989-2-21
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pubmed:abstractText |
Lysobactin, an antibiotic isolated from a strain of Lysobacter, is 2 to 4-fold more active than vancomycin against aerobic and anaerobic Gram-positive bacteria. Included in the spectrum of lysobactin are Staphylococci, Streptococci, corynebacteria, clostridia and various other Gram-positive anaerobic bacteria. The activity of lysobactin against aerobic and anaerobic Gram-negative bacteria is poor. When given parenterally the compound was efficacious in systemic staphylococcal and streptococcal infections in mice. Similarly, when applied topically lysobactin was also curative in a staphylococcal wound infection in mice. Some studies on the mode of action of lysobactin are presented.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Depsipeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Vancomycin,
http://linkedlifedata.com/resource/pubmed/chemical/lysobactin
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-8820
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1745-51
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3209466-Animals,
pubmed-meshheading:3209466-Anti-Bacterial Agents,
pubmed-meshheading:3209466-Bacterial Infections,
pubmed-meshheading:3209466-Cell Wall,
pubmed-meshheading:3209466-Depsipeptides,
pubmed-meshheading:3209466-Mice,
pubmed-meshheading:3209466-Microbial Sensitivity Tests,
pubmed-meshheading:3209466-Oligopeptides,
pubmed-meshheading:3209466-Vancomycin
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pubmed:year |
1988
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pubmed:articleTitle |
Lysobactin, a novel antibacterial agent produced by Lysobacter sp. II. Biological properties.
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pubmed:affiliation |
Squibb Institute for Medical Research, Princeton, New Jersey 08543-4000.
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pubmed:publicationType |
Journal Article
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