Linked Life Data

3208827

Source:http://linkedlifedata.com/resource/pubmed/id/3208827

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1989-2-23
pubmed:abstractText
The short-term cardiotoxic effects of gentamicin were studied on electrical and mechanical activities in cultures of ventricular confluent cardiocytes of rats. Application of gentamicin to the bath lowered the spontaneous action potential firing rate which was restored when the external calcium was elevated. Fast local application and withdrawal of drugs to non-pacemaker cells allowed effect/dose curves to be made. Such application of 200 nmol gentamicin (approximated concentration: 0.8 x 10(-3)-8.0 x 10(-3) M) lowered the contraction amplitude by 50% and the action potential overshoot by 20% while the action potential duration and maximum diastolic potential remained unchanged. Gentamicin withdrawal was followed by a rapid (half time = 5 s) and complete restoration of contraction. Verapamil, Mn2+, EDTA and La3+ also diminished contraction and overshoot but their effects were reversed 28, 25, 6 and 1.5 times more slowly, respectively. Gentamicin, like La3+, could act extracellularly, probably by competing with calcium ions for some external membrane site.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
111-20
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Gentamicin causes the fast depression of action potential and contraction in cultured cardiocytes.
pubmed:affiliation
INSERM U121, Hôpital Cardiovasculaire, Lyon, France.
pubmed:publicationType
Journal Article