pubmed-article:3208739 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3208739 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:3208739 | lifeskim:mentions | umls-concept:C0028581 | lld:lifeskim |
pubmed-article:3208739 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
pubmed-article:3208739 | lifeskim:mentions | umls-concept:C0004266 | lld:lifeskim |
pubmed-article:3208739 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
pubmed-article:3208739 | lifeskim:mentions | umls-concept:C0017645 | lld:lifeskim |
pubmed-article:3208739 | pubmed:issue | 11 | lld:pubmed |
pubmed-article:3208739 | pubmed:dateCreated | 1989-2-21 | lld:pubmed |
pubmed-article:3208739 | pubmed:abstractText | In an analysis of a 90-kb region around the human beta-globin gene complex we have identified at least eight sites of attachment to the nuclear scaffold (SARs). While these have many potential functions, there appears to be a particular association with sequences important in the regulation of the complex. Two SARs are close to the known enhancer-like elements of the beta-globin gene. SARs flanking the complex co-habit with the boundaries of the putative beta-like globin gene regulatory domain. In contrast, we have detected no SARs within a 140-kb region of the human alpha-globin gene complex. If SARs play a role in the regulation of gene expression then this structural difference would imply a difference in the regulation of the two complexes. | lld:pubmed |
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pubmed-article:3208739 | pubmed:language | eng | lld:pubmed |
pubmed-article:3208739 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3208739 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:3208739 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3208739 | pubmed:month | Nov | lld:pubmed |
pubmed-article:3208739 | pubmed:issn | 0261-4189 | lld:pubmed |
pubmed-article:3208739 | pubmed:author | pubmed-author:HiggsD RDR | lld:pubmed |
pubmed-article:3208739 | pubmed:author | pubmed-author:JarmanA PAP | lld:pubmed |
pubmed-article:3208739 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3208739 | pubmed:volume | 7 | lld:pubmed |
pubmed-article:3208739 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3208739 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3208739 | pubmed:pagination | 3337-44 | lld:pubmed |
pubmed-article:3208739 | pubmed:dateRevised | 2010-9-9 | lld:pubmed |
pubmed-article:3208739 | pubmed:meshHeading | pubmed-meshheading:3208739-... | lld:pubmed |
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pubmed-article:3208739 | pubmed:meshHeading | pubmed-meshheading:3208739-... | lld:pubmed |
pubmed-article:3208739 | pubmed:year | 1988 | lld:pubmed |
pubmed-article:3208739 | pubmed:articleTitle | Nuclear scaffold attachment sites in the human globin gene complexes. | lld:pubmed |
pubmed-article:3208739 | pubmed:affiliation | Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK. | lld:pubmed |
pubmed-article:3208739 | pubmed:publicationType | Journal Article | lld:pubmed |
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