rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
11
|
pubmed:dateCreated |
1989-2-21
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pubmed:abstractText |
In an analysis of a 90-kb region around the human beta-globin gene complex we have identified at least eight sites of attachment to the nuclear scaffold (SARs). While these have many potential functions, there appears to be a particular association with sequences important in the regulation of the complex. Two SARs are close to the known enhancer-like elements of the beta-globin gene. SARs flanking the complex co-habit with the boundaries of the putative beta-like globin gene regulatory domain. In contrast, we have detected no SARs within a 140-kb region of the human alpha-globin gene complex. If SARs play a role in the regulation of gene expression then this structural difference would imply a difference in the regulation of the two complexes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-1202042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3208739-16453673,
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
|
pubmed:issn |
0261-4189
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
7
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
3337-44
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pubmed:dateRevised |
2010-9-9
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pubmed:meshHeading |
pubmed-meshheading:3208739-Binding Sites,
pubmed-meshheading:3208739-Blotting, Southern,
pubmed-meshheading:3208739-Cell Nucleus,
pubmed-meshheading:3208739-DNA,
pubmed-meshheading:3208739-Gene Expression Regulation,
pubmed-meshheading:3208739-Globins,
pubmed-meshheading:3208739-Humans,
pubmed-meshheading:3208739-Multigene Family,
pubmed-meshheading:3208739-Nucleic Acid Hybridization,
pubmed-meshheading:3208739-Restriction Mapping
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pubmed:year |
1988
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pubmed:articleTitle |
Nuclear scaffold attachment sites in the human globin gene complexes.
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pubmed:affiliation |
Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK.
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pubmed:publicationType |
Journal Article
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