Linked Life Data

3202161

Source:http://linkedlifedata.com/resource/pubmed/id/3202161

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6 Pt 1
pubmed:dateCreated
1989-1-26
pubmed:abstractText
The effects of daily treatment with testosterone propionate (TP, 2 mg/kg) and dihydrotestosterone propionate (DHTP, 2 mg/kg) were examined in rhesus monkeys in three experiments. In experiments 1 and 2, males and females gonadectomized in infancy, and female pseudohermaphrodites produced by prenatal exposure to TP or DHTP and gonadectomized postpubertally, were studied in conjunction with intact males (IM). The IM group was heavier in adulthood than the three gonadectomized groups, which did not differ in body weight from each other. Genetic males had greater crown-rump length than genetic females. Treatment of the gonadectomized groups with TP produced large increases in body mass (averaging approximately 50%) that were attributable to accretion of lean tissue. This effect did not differ significantly between males and females. In experiment 3, additional groups of males that had been castrated as infants were given daily injections with DHTP or oil. The DHTP treatment resulted in increases in body size that were not different from those seen following TP treatment. When TP and DHPT treatments were discontinued, body weights and dimensions reverted to base-line values. Increased body size induced by TP and DHTP was accomplished without reliable increases in food intake. Because testosterone (T) is metabolized to dihydrotestosterone (DHT), while DHT cannot be converted to T, these results show that both T and DHT are effective anabolic hormones in rhesus.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
255
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E857-64
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Androgenic influences on body size and composition of adult rhesus monkeys.
pubmed:affiliation
Wisconsin Regional Primate Research Center, University of Wisconsin-Madison 53715-1299.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.