Linked Life Data

3189308

Source:http://linkedlifedata.com/resource/pubmed/id/3189308

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-12-12
pubmed:abstractText
Studies of the inheritance of the platelet-specific alloantigens PlA1/PlA2 and Baka/Bakb in informative families provided evidence that the genes determining PlA and Bak antigens are in close genetic linkage (P = .004). In 154 normal, unrelated Caucasian subjects it was found that the antigen PlA1 is associated with Baka and the antigen PlA2 with Bakb more often than would be expected by chance (P less than .05). Bak and PlA antigens are carried on platelet membrane glycoproteins IIb and IIIa, respectively, which are decreased or absent in the inherited platelet disorder Glanzmann's thrombasthenia. Thus, the findings suggest that the defect in this disease involves two closely linked genes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0361-8609
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-43
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Probable genetic linkage between genes coding for platelet-specific antigens of the PlA and Bak systems.
pubmed:affiliation
Blood Center of Southeastern Wisconsin, Inc., Milwaukee 53233.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.