Linked Life Data

3187303

Source:http://linkedlifedata.com/resource/pubmed/id/3187303

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8-9
pubmed:dateCreated
1988-12-21
pubmed:abstractText
Cerebrovascular disorders are frequent in sickle-cell anemia. They occur mainly in homozygous children. Traditionally, they were believed to result from an arteriolar sickle-cell thrombosis, the "sludge" phenomenon, which is generally responsible for sickle cell anemia disorders. It is now well known that several other kinds of cerebral damages are involved such as moya-moya syndrome, cerebral hemorrhage, subdural hematoma, extra-dural hematoma and cerebral thrombophlebitis. In this disease, the identification of these different processes cannot be always made by a simple clinical examination. However, specific therapies are sometimes necessary, such as neurosurgical intervention in the case of aneurysm or hematoma, and, according to some authors, the necessity of repeated appropriate transfusions, in the case of moya-moya. So it is imperative to carry out without delay a complete neuroradiological assessment of the lesions. At present, the most widely accepted theory to explain the arteriolar lesions, is that they result from a sickle-cell thrombosis of the vasa-vasorum, but, we think it is not the only valid hypothesis and we think that other phenomena may be involved with a genetic factor (patients with connective tissue disorders may have a particular genotype), and with infectious or autoimmune or coagulation disorders, the latter being frequently observed in this disease.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0035-3787
pubmed:author
pubmed:issnType
Print
pubmed:volume
144
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
465-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[Cerebrovascular complications of sickle-cell anemia].
pubmed:affiliation
Centre Hospitalier de Fort de France, Martinique.
pubmed:publicationType
Journal Article, English Abstract, Case Reports