Linked Life Data

3183306

Source:http://linkedlifedata.com/resource/pubmed/id/3183306

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-12-15
pubmed:abstractText
The effect of advancing age on the chronobiology of testosterone (T) and luteinizing hormone (LH) secretion in healthy men was investigated. Twenty young (average age 30.4 yrs) and 14 elderly (average age 70.4 yrs) men underwent 10 min blood sampling for 25 hrs to evaluate the circadian periodicity of LH, LH pulse frequency, and T. Using cosinor regression analysis, young men were found to have a significant (p less than .05) circadian variation in LH pulse frequency, with slowing of LH pulses during the night (maximum slowing at 2230 hr). There was also a tendency for LH pulse amplitude to increase at night (p = .06) in young men. However, no significant circadian pattern in LH pulse frequency or amplitude was detected in the elderly men. Mean LH by radioimmunoassay (RIA) and bioassay did not vary over the 24-hr period in either age group. Both young and elderly men had significant circadian rhythms in serum T, although the rhythm in elderly men was considerably blunted and was shifted in time compared to the young. These data provide evidence for age-related changes in the circadian rhythms of LH pulse frequency and T secretion and suggest that the LHRH pulse generator loses its circadian rhythmicity with normal aging in men.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1422
pubmed:author
pubmed:issnType
Print
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
M163-9
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Age-related alterations in the circadian rhythms of pulsatile luteinizing hormone and testosterone secretion in healthy men.
pubmed:affiliation
Department of Medicine, University of Washington, Seattle.
pubmed:publicationType
Journal Article