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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1988-12-15
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pubmed:abstractText |
Twelve hospitalised patients, affected by biliary tract infections, were treated with cefotetan at dosages ranging between 4 and 6 g daily i.v. In only 11 patients was the aetiological agent identified. Eleven patients (91.67%) completely recovered from their infections and the pathogens were eradicated; the treatment failed in only 1 patient (8.33%). Furthermore, determinations were made of cefotetan concentrations in serum, gallbladder bile, gallbladder wall and gallstones of 14 patients undergoing cholecystectomy: in 7 patients after only 1 injection i.v. of 2 g and in 7 patients after 7 injections i.v. of 2 g at intervals of 12 h. The levels recorded were several times higher than the minimum inhibitory concentrations against bacteria that are most often responsible for biliary infections. Cefotetan is a promising and effective antimicrobial agent in the therapy of biliary tract infections.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0392-906X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
233-6
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3180302-Adult,
pubmed-meshheading:3180302-Aged,
pubmed-meshheading:3180302-Bacterial Infections,
pubmed-meshheading:3180302-Biliary Tract Diseases,
pubmed-meshheading:3180302-Cefotetan,
pubmed-meshheading:3180302-Cholecystectomy,
pubmed-meshheading:3180302-Female,
pubmed-meshheading:3180302-Humans,
pubmed-meshheading:3180302-Injections, Intravenous,
pubmed-meshheading:3180302-Male,
pubmed-meshheading:3180302-Middle Aged
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pubmed:year |
1988
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pubmed:articleTitle |
Clinical and pharmacokinetic study of cefotetan in biliary tract infections: preliminary report.
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pubmed:affiliation |
Institute of Internal Medicine, 1st Medical School, Naples University, Italy.
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pubmed:publicationType |
Journal Article
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