Linked Life Data

3179034

Source:http://linkedlifedata.com/resource/pubmed/id/3179034

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-12-1
pubmed:abstractText
The relative potency of chemicals as promoting agents in multistage hepatocarcinogenesis has been previously defined as the Promotion Index through calculations of quantitative stereology. The Promotion Index is a function of the total cell population of altered hepatic foci in the liver at any given time and dose of promoting agent. When the Promotion Index was determined as a function of the dose of phenobarbital given in the diet for varying periods of time, a value of 394 was obtained for doses less than 0.01%; at doses between 0.01% and 0.1%, the Promotion Index was found to be 47. These values were obtained by the extrapolation of slopes of the Promotion Indices at various doses and durations of administration of phenobarbital. The volume percentages of the liver occupied by seven possible phenotypes using three different markers (gamma-glutamyltranspeptidase, canalicular ATPase and glucose-6-phosphatase) were relatively constant in distribution for up to one year of phenobarbital administration except at the two highest doses employed, 0.5% and 0.1%, at which a maximal effect of the promoting agent has been obtained. Possible mechanisms for the biphasic relationship of the Promotion Index of phenobarbital with the dose and time of administration are discussed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0903-465X
pubmed:author
pubmed:issnType
Print
pubmed:volume
2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
262-74
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The effects of dose and duration of administration on the promotion index of phenobarbital in multistage hepatocarcinogenesis in the rat.
pubmed:affiliation
McArdle Laboratory for Cancer Research, Department of Oncology, Medical School, University of Wisconsin, Madison 53706.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't