Linked Life Data

3178804

Source:http://linkedlifedata.com/resource/pubmed/id/3178804

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-11-21
pubmed:abstractText
Increasing data strongly suggest that, in adults, the G gamma/A gamma globin chains ratio is genetically controlled by determinants linked in cis to the beta-globin gene cluster. The presence of the C----T substitution at position -158 5' to the G gamma globin gene in subjects displaying high G gamma/A gamma globin chains ratio led to the hypothesis that this substitution is involved in the determination of high G gamma globin gene expression. In order to test this hypothesis, we have compared the expression of two G gamma globin genes carrying a C or a T at position -158, upon transfection into a COS cell line or stable integration into a MEL cell line. Our results showed no significant effect of the nucleotide at position -158 on the level of human G gamma mRNA produced in these cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-291X
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
155
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1213-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Expression of human G gamma globin genes carrying a T or a C at position -158 in COS and MEL cells.
pubmed:affiliation
Laboratoire de Biologie Cellulaire (C.N.R.S.-UMR0004), Université de Lyon-I, Villeurbanne, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't