Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
1988-11-18
|
| pubmed:abstractText |
The structure-activity relationship for 7-arylacetamido cephalosporins has been extended. Modifications of the 7-aryl group led to improvements in microbiological activity against Gram-positive organisms. However, Gram-negative activity was generally much poorer than that of the lead compound 7-[(2-aminothiazol-4-yl)acetamido]-3-chloro-cephalosporanic acid (A). Modifications of the 3-position did not significantly change the microbiological activity or spectrum. Of the compounds selected for mouse protection studies (ED50's), 7-[(benzothien-3-yl)acetamido]-3-chloro cephalosporin and A showed the best per oral to subcutaneous ED50 ratios.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-2623
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1993-7
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3172135-Administration, Oral,
pubmed-meshheading:3172135-Animals,
pubmed-meshheading:3172135-Bacterial Infections,
pubmed-meshheading:3172135-Biological Availability,
pubmed-meshheading:3172135-Cephalosporins,
pubmed-meshheading:3172135-Gram-Negative Bacteria,
pubmed-meshheading:3172135-Gram-Positive Bacteria,
pubmed-meshheading:3172135-Mice,
pubmed-meshheading:3172135-Microbial Sensitivity Tests,
pubmed-meshheading:3172135-Structure-Activity Relationship
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Oral absorption of cephalosporin antibiotics. 2. Expanded structure-activity relationships of 7-(arylacetamido)-3-substituted cephalosporins.
|
| pubmed:affiliation |
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.
|
| pubmed:publicationType |
Journal Article
|