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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1988-11-10
|
| pubmed:abstractText |
The role of endogenously activated protein kinase C in calcium-activated exocytosis was examined in digitonin-permeabilised bovine adrenal chromaffin cells. Protein kinase C activity was reduced by down-regulation following long-term treatment with PMA or by using the inhibitor sphingosine. Both treatments resulted in a substantial reduction in catecholamine secretion elicited by micromolar calcium, indicating that endogenous activation of protein kinase C is a major requirement for calcium-activated exocytosis in chromaffin cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0014-5793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
26
|
| pubmed:volume |
238
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
151-5
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3169247-Adrenal Medulla,
pubmed-meshheading:3169247-Animals,
pubmed-meshheading:3169247-Calcium,
pubmed-meshheading:3169247-Cattle,
pubmed-meshheading:3169247-Cell Membrane Permeability,
pubmed-meshheading:3169247-Cells, Cultured,
pubmed-meshheading:3169247-Exocytosis,
pubmed-meshheading:3169247-Kinetics,
pubmed-meshheading:3169247-Protein Kinase C,
pubmed-meshheading:3169247-Sphingosine,
pubmed-meshheading:3169247-Tetradecanoylphorbol Acetate
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
A major role for protein kinase C in calcium-activated exocytosis in permeabilised adrenal chromaffin cells.
|
| pubmed:affiliation |
Physiological Laboratory, University of Liverpool, England.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|