| pubmed-article:3161445 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3161445 | lifeskim:mentions | umls-concept:C0687725 | lld:lifeskim |
| pubmed-article:3161445 | lifeskim:mentions | umls-concept:C1257890 | lld:lifeskim |
| pubmed-article:3161445 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:3161445 | lifeskim:mentions | umls-concept:C0007193 | lld:lifeskim |
| pubmed-article:3161445 | lifeskim:mentions | umls-concept:C0205100 | lld:lifeskim |
| pubmed-article:3161445 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:3161445 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3161445 | pubmed:dateCreated | 1985-9-11 | lld:pubmed |
| pubmed-article:3161445 | pubmed:abstractText | In order to test the hypothesis of the role of a suppressor/cytotoxic T lymphocyte deficit in the pathogenesis of dilated cardiomyopathies (DCM), 20 patients (11 alcoholic-A; 9 primary-P) were compared with 24 normal controls (N) and 10 patients with chronic cardiac failure (CCF). The percentage of OKT 3, a global assessment of the T lymphocytes, did not differ significantly between the groups. The percentage of OKT 4 (helper T lymphocytes) was significantly lower in DCM (43 +/- 8.1 p. 100) compared to N (51.92 +/- 8.1 p. 100), p less than 0.001. The percentage of OKT 4 was also lower in CCF (45.3 +/- 3.91 p. 100) compared to N (p less than 0.05). There was a very significant decrease in the percentage of OKT 8 (suppressor/cytotoxic T lymphocytes) in DCM (17.23 +/- 4.78 p. 100) compared to N (26.42 +/- 5.72 p. 100) (p less than 10(-8)). A reduction of OKT 8 was also observed in CCF compared to N (p less than 0.05). The ratio of OKT 4/OKT 8 was significantly higher in DCM (2.7 +/- 0.97) compared to N (2.08 +/- 0.6) (p less than 0.05). This difference was not observed in CCF (2.19 +/- 0.48). There were no differences between DCM A and P. These results indicate that chronic cardiac failure is associated with an equal reduction in the percentage of OKT 4 and OKT 8 lymphocytes. Dilated cardiomyopathy is associated with a large reduction in the OKT 4 and especially in the of OKT 8 with a statistically significant increase in the OKT 4/OKT 8 ratio. Although chronic cardiac failure seems to affect lymphocytes, these results are compatible with a deficit of suppressor/cytotoxic T lymphocytes in dilated cardiomyopathies. | lld:pubmed |
| pubmed-article:3161445 | pubmed:language | fre | lld:pubmed |
| pubmed-article:3161445 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3161445 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3161445 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3161445 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3161445 | pubmed:issn | 0003-410X | lld:pubmed |
| pubmed-article:3161445 | pubmed:author | pubmed-author:LanfranchiJJ | lld:pubmed |
| pubmed-article:3161445 | pubmed:author | pubmed-author:SachsR NRN | lld:pubmed |
| pubmed-article:3161445 | pubmed:author | pubmed-author:HatronP YPY | lld:pubmed |
| pubmed-article:3161445 | pubmed:author | pubmed-author:SaizyCC | lld:pubmed |
| pubmed-article:3161445 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3161445 | pubmed:volume | 136 | lld:pubmed |
| pubmed-article:3161445 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3161445 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3161445 | pubmed:pagination | 229-32 | lld:pubmed |
| pubmed-article:3161445 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:3161445 | pubmed:meshHeading | pubmed-meshheading:3161445-... | lld:pubmed |
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| pubmed-article:3161445 | pubmed:meshHeading | pubmed-meshheading:3161445-... | lld:pubmed |
| pubmed-article:3161445 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:3161445 | pubmed:articleTitle | [Peripheral T-lymphocyte subpopulations in primary and alcoholic dilated cardiomyopathy]. | lld:pubmed |
| pubmed-article:3161445 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3161445 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3161445 | pubmed:publicationType | English Abstract | lld:pubmed |
