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rdf:type |
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lifeskim:mentions |
umls-concept:C0007603,
umls-concept:C0017262,
umls-concept:C0018270,
umls-concept:C0019764,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0021745,
umls-concept:C0080103,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0205460,
umls-concept:C0230664,
umls-concept:C0431085,
umls-concept:C1265611,
umls-concept:C1280500,
umls-concept:C1510827,
umls-concept:C2911684
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|
pubmed:issue |
1
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|
pubmed:dateCreated |
1985-8-26
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pubmed:abstractText |
A large difference in the number of gamma-IFN receptors was found on a variety of human tumor cell lines with a range of 0.4 to 15 X 10(3) binding sites/cell. The receptor number did not correlate with the potential responsiveness of the cells to gamma-IFN, in regard to either growth inhibition or induction of HLA-DR expression, two independently regulated gamma-IFN effects. However, with respect to HLA-DR expression it was found that the gamma-IFN sensitivity of inducible cell lines depended on the number of receptors, so that with increasing number of receptors present on these cells lower doses of gamma-IFN were required for induction of the gamma-IFN effect.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0020-7136
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
36
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
103-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3160668-Cell Division,
pubmed-meshheading:3160668-Cell Line,
pubmed-meshheading:3160668-Colonic Neoplasms,
pubmed-meshheading:3160668-HLA-DR Antigens,
pubmed-meshheading:3160668-Histocompatibility Antigens Class II,
pubmed-meshheading:3160668-Humans,
pubmed-meshheading:3160668-Interferon-gamma,
pubmed-meshheading:3160668-Leukemia,
pubmed-meshheading:3160668-Neoplasms,
pubmed-meshheading:3160668-Receptors, Immunologic,
pubmed-meshheading:3160668-Receptors, Interferon
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pubmed:year |
1985
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pubmed:articleTitle |
Biological effects of gamma-interferon on human tumor cells: quantity and affinity of cell membrane receptors for gamma-IFN in relation to growth inhibition and induction of HLA-DR expression.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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