Linked Life Data

3158903

Source:http://linkedlifedata.com/resource/pubmed/id/3158903

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1985-7-5
pubmed:abstractText
Metronidazole is widely used for the prevention and treatment of post-operative anaerobic infections. In this study, the prophylactic effectiveness of metronidazole suppositories was tested in patients undergoing abdominal surgery. The suppositories had previously been tested in healthy subjects for drug absorption and tolerance. Patients were divided into three treatment groups: one group received the drug intravenously, another as suppositories and the third one by both routes. Clinical effectiveness was evaluated and plasma metronidazole levels were measured. On the basis of the results obtained, we suggest that a 1 g suppository should be administered 8-hourly over the 20 hours preceding surgery, then 12-hourly if preparation of the digestive tract can be inserted between two administrations. In emergency surgery, 1 suppository must be given at least 1 hour before induction, the 12-hourly, and a 500 mg intravenous infusion at the time of induction.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0755-4982
pubmed:author
pubmed:issnType
Print
pubmed:day
13
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
823-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
[Prevention of postoperative anaerobic bacterial infections in abdominal surgery with metronidazole suppositories].
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, English Abstract, Randomized Controlled Trial