rdf:type |
|
lifeskim:mentions |
umls-concept:C0005528,
umls-concept:C0017725,
umls-concept:C0021641,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205112,
umls-concept:C0205409,
umls-concept:C0206131,
umls-concept:C1623517,
umls-concept:C1948023,
umls-concept:C2349975
|
pubmed:issue |
2
|
pubmed:dateCreated |
1985-6-6
|
pubmed:abstractText |
The C-kinase activating phorbolester TPA (12-O-Tetradecanoyl-beta-phorbol-13-acetate) and PdBu (4-beta-Phorbol-12,13,dibutyrate) stimulated D-glucose transport twofold in isolated rat adipocytes but inhibited high affinity insulin binding and the responsiveness of D-glucose transport to insulin stimulation by about 30%. Phorbolesters have therefore insulin-like effects but antagonize insulin on receptor and postreceptor level.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol 12,13-Dibutyrate,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbol Esters,
http://linkedlifedata.com/resource/pubmed/chemical/Phorbols,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
|
pubmed:issn |
0006-291X
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
30
|
pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
824-32
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3158314-Adipose Tissue,
pubmed-meshheading:3158314-Animals,
pubmed-meshheading:3158314-Biological Transport, Active,
pubmed-meshheading:3158314-Glucose,
pubmed-meshheading:3158314-Insulin,
pubmed-meshheading:3158314-Male,
pubmed-meshheading:3158314-Phorbol 12,13-Dibutyrate,
pubmed-meshheading:3158314-Phorbol Esters,
pubmed-meshheading:3158314-Phorbols,
pubmed-meshheading:3158314-Protein Kinase C,
pubmed-meshheading:3158314-Protein Kinases,
pubmed-meshheading:3158314-Protein-Tyrosine Kinases,
pubmed-meshheading:3158314-Rats,
pubmed-meshheading:3158314-Rats, Inbred Strains,
pubmed-meshheading:3158314-Receptor, Insulin,
pubmed-meshheading:3158314-Tetradecanoylphorbol Acetate
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pubmed:year |
1985
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pubmed:articleTitle |
Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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