Linked Life Data

3157658

Source:http://linkedlifedata.com/resource/pubmed/id/3157658

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-6-20
pubmed:abstractText
The effects of insulin infusion (1.5 u/h and 15 u/h) on finger nailfold capillary diameter, microcirculatory resting flow and microvascular reactivity were studied in eleven Type 1 diabetics. Blood glucose was maintained at pre-infusion values by intravenous glucose infusion as necessary. Venous limb capillary diameter was significantly wider on 15 u/h compared with pre-infusion values (14.3 +/- 4.5 micron pre, 16.9 +/- 5.1 micron 15 u/h, p less than 0.01. Resting blood flow measured by laser doppler flowmetry increased on the low dose infusion compared with pre-infusion values (2.6 +/- 1.7 V pre, 3.3 +/- 1.9 V 1.5 mu/h, p less than 0.05) but fell on high dose infusion (2.5 +/- 1.9 V, p less than 0.02). Dynamic measurement of capillary blood flow velocity in single capillaries suggested that insulin infusion increased the circulatory debt repayment following 60 s arterial occlusion. The high dose infusion caused a significant impairment of the reflex rise in precapillary resistance that normally accompanies venous congestion. It is concluded that insulin has effects on skin microvascular haemodynamics that are independent of the hormone's hypoglycaemic action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0167-6865
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
69-83
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
The effects of intravenous insulin infusion on skin microcirculatory flow in Type 1 diabetes.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't