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rdf:type |
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|
lifeskim:mentions |
|
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pubmed:issue |
4
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pubmed:dateCreated |
1989-5-26
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pubmed:abstractText |
Isolated pancreatic islets from mice were perifused with media containing maximally effective concentrations of glibenclamide (0.1-10 mumol/l) or glipizide (1 mumol/l). In these islets an increase of the glucose concentration from 10 mmol/l to 40 mmol/l or addition of D-glyceraldehyde (20 mmol/l) caused a temporary decrease in insulin release which was followed by a sustained enhancement of release. alpha-Ketoisocaproate (3 or 20 mmol/l) did not inhibit insulin release; at high concentration it was an even stronger secretagogue than D-glucose or D-glyceraldehyde. It is concluded that high energy phosphates couple B-cell fuel metabolism and insulin release by acting both on the ATP-dependent K+ channel and on other targets not yet identified.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-1298
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
338
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
459-62
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3149719-Animals,
pubmed-meshheading:3149719-Cell Membrane,
pubmed-meshheading:3149719-Glipizide,
pubmed-meshheading:3149719-Glucose,
pubmed-meshheading:3149719-Glyburide,
pubmed-meshheading:3149719-Insulin,
pubmed-meshheading:3149719-Iodine Radioisotopes,
pubmed-meshheading:3149719-Islets of Langerhans,
pubmed-meshheading:3149719-Keto Acids,
pubmed-meshheading:3149719-Male,
pubmed-meshheading:3149719-Mice,
pubmed-meshheading:3149719-Sulfonylurea Compounds
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pubmed:year |
1988
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pubmed:articleTitle |
Glucose both inhibits and stimulates insulin secretion from isolated pancreatic islets exposed to maximally effective concentrations of sulfonylureas.
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pubmed:affiliation |
Institut für Pharmakologie und Toxikologie, Universität Göttingen, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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