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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1989-5-15
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pubmed:abstractText |
Ritanserin (1.0 and 2.5 mg/kg i.p.) was administered to rats before the start, of the light period, and sleep was recorded during the subsequent 12 h. The higher dose reduced sleep in the first 3 h. Both doses caused a more prolonged suppression of REM sleep. Spectral analysis of the EEG in non-REM sleep showed an increase of power density in the low frequency range (1.5-6 Hz) and a depression in the high frequency range (8-25 Hz). Since these changes differ from those previously observed after sleep deprivation, it is premature to conclude that the drug induces a physiological sleep intensification.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2999
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
156
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
275-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3149244-Animals,
pubmed-meshheading:3149244-Dose-Response Relationship, Drug,
pubmed-meshheading:3149244-Electroencephalography,
pubmed-meshheading:3149244-Male,
pubmed-meshheading:3149244-Piperidines,
pubmed-meshheading:3149244-Rats,
pubmed-meshheading:3149244-Rats, Inbred Strains,
pubmed-meshheading:3149244-Ritanserin,
pubmed-meshheading:3149244-Sleep Stages
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pubmed:year |
1988
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pubmed:articleTitle |
Effect of ritanserin on sleep stages and sleep EEG in the rat.
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pubmed:affiliation |
Institute of Pharmacology, University of Zürich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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