| pubmed-article:3148489 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3148489 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:3148489 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:3148489 | lifeskim:mentions | umls-concept:C0024547 | lld:lifeskim |
| pubmed-article:3148489 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:3148489 | lifeskim:mentions | umls-concept:C0013139 | lld:lifeskim |
| pubmed-article:3148489 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:3148489 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3148489 | pubmed:dateCreated | 1989-5-11 | lld:pubmed |
| pubmed-article:3148489 | pubmed:abstractText | The chromosomal locations of several genes responsible for increased malathion resistance in a laboratory-selected population of Drosophila melanogaster have been determined. These genes appear to be involved in the regulation of microsomal cytochrome P-450. A major gene on chromosome 2 (2-64) and at least two genes on chromosome 3 (near 3-58) control increased mixed function oxidase activity, and both larval and adult malathion resistance. Although the chromosome 2 locus was not associated with a significant increase in cytochrome P-450 content, SDS polyacrylamide gel electrophoresis of microsomal proteins detected increased silver staining of a polypeptide having a relative molecular mass (Mr) of about 52,000. Microsomes from strains carrying the chromosome 3 factors for resistance contained more cytochrome P-450 and increased amounts of two heme-staining protein bands (Mr = 50,000 and 54,000). The genes regulating these proteins were closely linked to striped at 3-62 and probably identical to the loci responsible for malathion resistance and increased mixed function oxidase activity. Other R genes on both chromosomes 2 and 3 as well as target resistance were required for the full expression of malathion resistance in the selected Drosophila population. Exposure of this Drosophila melanogaster population to malathion selected a polygenic system for the oxidative metabolism of insecticide. | lld:pubmed |
| pubmed-article:3148489 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3148489 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3148489 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3148489 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3148489 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3148489 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3148489 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3148489 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3148489 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3148489 | pubmed:issn | 0831-2796 | lld:pubmed |
| pubmed-article:3148489 | pubmed:author | pubmed-author:MortonR ARA | lld:pubmed |
| pubmed-article:3148489 | pubmed:author | pubmed-author:HouptD RDR | lld:pubmed |
| pubmed-article:3148489 | pubmed:author | pubmed-author:PurseyJ CJC | lld:pubmed |
| pubmed-article:3148489 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3148489 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:3148489 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3148489 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3148489 | pubmed:pagination | 844-53 | lld:pubmed |
| pubmed-article:3148489 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3148489 | pubmed:meshHeading | pubmed-meshheading:3148489-... | lld:pubmed |
| pubmed-article:3148489 | pubmed:meshHeading | pubmed-meshheading:3148489-... | lld:pubmed |
| pubmed-article:3148489 | pubmed:meshHeading | pubmed-meshheading:3148489-... | lld:pubmed |
| pubmed-article:3148489 | pubmed:meshHeading | pubmed-meshheading:3148489-... | lld:pubmed |
| pubmed-article:3148489 | pubmed:meshHeading | pubmed-meshheading:3148489-... | lld:pubmed |
| pubmed-article:3148489 | pubmed:meshHeading | pubmed-meshheading:3148489-... | lld:pubmed |
| pubmed-article:3148489 | pubmed:meshHeading | pubmed-meshheading:3148489-... | lld:pubmed |
| pubmed-article:3148489 | pubmed:meshHeading | pubmed-meshheading:3148489-... | lld:pubmed |
| pubmed-article:3148489 | pubmed:meshHeading | pubmed-meshheading:3148489-... | lld:pubmed |
| pubmed-article:3148489 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3148489 | pubmed:articleTitle | Genes controlling malathion resistance in a laboratory-selected population of Drosophila melanogaster. | lld:pubmed |
| pubmed-article:3148489 | pubmed:affiliation | Department of Biology, McMaster University, Hamilton, Ont., Canada. | lld:pubmed |
| pubmed-article:3148489 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3148489 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3148489 | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3148489 | lld:pubmed |
