Linked Life Data

3148489

Source:http://linkedlifedata.com/resource/pubmed/id/3148489

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-5-11
pubmed:abstractText
The chromosomal locations of several genes responsible for increased malathion resistance in a laboratory-selected population of Drosophila melanogaster have been determined. These genes appear to be involved in the regulation of microsomal cytochrome P-450. A major gene on chromosome 2 (2-64) and at least two genes on chromosome 3 (near 3-58) control increased mixed function oxidase activity, and both larval and adult malathion resistance. Although the chromosome 2 locus was not associated with a significant increase in cytochrome P-450 content, SDS polyacrylamide gel electrophoresis of microsomal proteins detected increased silver staining of a polypeptide having a relative molecular mass (Mr) of about 52,000. Microsomes from strains carrying the chromosome 3 factors for resistance contained more cytochrome P-450 and increased amounts of two heme-staining protein bands (Mr = 50,000 and 54,000). The genes regulating these proteins were closely linked to striped at 3-62 and probably identical to the loci responsible for malathion resistance and increased mixed function oxidase activity. Other R genes on both chromosomes 2 and 3 as well as target resistance were required for the full expression of malathion resistance in the selected Drosophila population. Exposure of this Drosophila melanogaster population to malathion selected a polygenic system for the oxidative metabolism of insecticide.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0831-2796
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
844-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Genes controlling malathion resistance in a laboratory-selected population of Drosophila melanogaster.
pubmed:affiliation
Department of Biology, McMaster University, Hamilton, Ont., Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't