Linked Life Data

3141995

Source:http://linkedlifedata.com/resource/pubmed/id/3141995

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-12-22
pubmed:abstractText
The nature of the skin tumor promotion response to a hydroperoxide metabolite of butylated hydroxytoluene, 2,6-di-tert-butyl-4-hydroperoxyl-2,5-cyclohexadienone (BHTOOH), was examined in SENCAR mice. BHTOOH was an effective inducer of epidermal ornithine decarboxylase (ODC) activity. Maximal induction of ODC activity was observed 12 hours after a single application of BHTOOH. Dose-dependent increases were seen between 2 and 20 mumol while higher amounts were less effective. A similar dose-response relationship for papilloma and carcinoma formation was observed when BHTOOH was applied twice weekly for 50 weeks to mice previously initiated with 7,12-dimethylbenz[a]anthracene. Doses of 2, 8, and 20 mumol BHTOOH gave maximal papilloma responses of 0.1, 0.6, and 3.6 papillomas/mouse, respectively. The progression of papillomas to carcinomas was examined and at 60 weeks the incidence of carcinomas was 0, 17, and 28% for the three treatment groups. The carcinoma:papilloma ratios were 0.08 and 0.40 for the high and intermediate BHTOOH dose groups. The data suggest that BHTOOH, unlike butylated hydroxytoluene, is an effective tumor promoter in mouse skin. Additionally, BHTOOH may enhance the conversion of papillomas to carcinomas. However, BHTOOH is not a complete carcinogen in that no papillomas or carcinomas were observed in uninitiated mice treated with BHTOOH only.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
61
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
291-303
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Tumor promotion by a hydroperoxide metabolite of butylated hydroxytoluene, 2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone, in mouse skin.
pubmed:affiliation
Department of Environmental Health Sciences, Johns Hopkins School of Hygiene and Public Health, Baltimore, Maryland 21205.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't