Linked Life Data

3141333

Source:http://linkedlifedata.com/resource/pubmed/id/3141333

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-12-21
pubmed:abstractText
Increasing interest in events regulating gonadotropin synthesis and secretion led to the reexamination, by radioimmunoassay (RIA), of the pituitary content of luteinizing hormone (LH) and follicle stimulating hormone (FSH). In a preliminary experiment, the importance of the composition of the solvent used to homogenize pituitaries on the detection of LH and FSH was demonstrated by RIA. Experiment 1 demonstrated that a drop in pituitary FSH occurred acutely following gonadectomy in males, but not in females. Experiment 2 tested whether this decline resulted from loss of testosterone or inhibin. Males were castrated and treated daily with oil or testosterone propionate, porcine follicular fluid, porcine serum, or testosterone plus follicular fluid for 2 to 14 days. Castration lowered pituitary FSH at 2, 4, and 6 days. Follicular fluid suppressed serum FSH, but not LH, and did not prevent the fall in pituitary FSH. Testosterone blocked the rise of serum LH and FSH and prevented the decline in pituitary FSH.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0196-3635
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
294-304
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:articleTitle
Pituitary gonadotropin content in gonadectomized rats. Immunoassay measurements influenced by extraction solvent and testosterone replacement.
pubmed:affiliation
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60201.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.