Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1988-10-12
|
| pubmed:abstractText |
In a prospective, controlled, double-blind study, 37 patients with major depressive disorder were subclassified into primary depression (N = 25) and secondary (N = 12) depression and treated with either amitriptyline (primary depressives N = 13, secondary depressives N = 6) or bupropion (primary depressives N = 12, secondary depressives N = 6). A differential response to the novel antidepressant bupropion was observed between the two diagnostic subgroups, but no differential response to amitriptyline was observed; patients with primary depression and secondary depression responded equally well to amitriptyline but not to bupropion. Our results provide pharmacological evidence supporting the usefulness of this subclassification of depression.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0160-6689
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
49
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
310-2
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3137218-Adolescent,
pubmed-meshheading:3137218-Adult,
pubmed-meshheading:3137218-Amitriptyline,
pubmed-meshheading:3137218-Antidepressive Agents,
pubmed-meshheading:3137218-Anxiety Disorders,
pubmed-meshheading:3137218-Bupropion,
pubmed-meshheading:3137218-Clinical Trials as Topic,
pubmed-meshheading:3137218-Depressive Disorder,
pubmed-meshheading:3137218-Double-Blind Method,
pubmed-meshheading:3137218-Drug Administration Schedule,
pubmed-meshheading:3137218-Drug Evaluation,
pubmed-meshheading:3137218-Female,
pubmed-meshheading:3137218-Humans,
pubmed-meshheading:3137218-Male,
pubmed-meshheading:3137218-Pilot Projects,
pubmed-meshheading:3137218-Propiophenones,
pubmed-meshheading:3137218-Prospective Studies,
pubmed-meshheading:3137218-Random Allocation
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Differential effect of amitriptyline and bupropion on primary and secondary depression: a pilot study.
|
| pubmed:affiliation |
Department of Psychiatry, University of Kansas Medical Center, Kansas City 66103.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Controlled Clinical Trial,
Research Support, Non-U.S. Gov't
|