Linked Life Data

3135200

Source:http://linkedlifedata.com/resource/pubmed/id/3135200

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-9-7
pubmed:abstractText
To analyze the role of endogenous opioids on epileptogenesis the effect of repeated doses of naloxone alone (NA) (2, 4, and 8 mg/kg every 15 min) or along with intermittent photic stimulation (NPS) (1, 3, and 10 Hz) was tested on acute "Encephale isolé" cats. The electrical activity recordings of sensorimotor cortex (SMC), visual cortex, and right and left amygdalae revealed progressive changes as naloxone was administered: (A) slow spindle activity (4-6 Hz) in SMC, (B) 12 Hz rhythmic activity in both amygdalae, (C) generalized paroxysms, and (D) spontaneous tonic-clonic electrographic seizures. These changes occurred in both experimental groups (NA, NPS), and their onset was dose-related. Photic stimulation precipitated these phenomena. The amplitude of the visual evoked potential components (N1-P1, P1-N2, N2-P2) and power spectral analysis of spontaneous and evoked activity underwent progressive changes. Our results confirm a facilitatory effect of naloxone on epileptogenesis and suggest a possible role of endogenous opioids in this process and on sensory pathways' excitability.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
159-75
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Naloxone facilitates sensory precipitation of focal and generalized seizures: evoked potentials and power spectral analysis in the cat.
pubmed:affiliation
Instituto Mexicano de Psiquiatría, División de Investigaciones en Neurociencias, DF.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't