rdf:type |
|
lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0013216,
umls-concept:C0030705,
umls-concept:C0087111,
umls-concept:C0205101,
umls-concept:C0205179,
umls-concept:C0205263,
umls-concept:C0596790,
umls-concept:C0600558,
umls-concept:C1274040,
umls-concept:C1517927,
umls-concept:C1522449
|
pubmed:issue |
10
|
pubmed:dateCreated |
1988-6-7
|
pubmed:abstractText |
Ninety-eight patients with locally advanced breast cancer (Stage IIIA-IIIB) were entered into a pilot study combining intensive induction (neoadjuvant) chemotherapy (VTMFAP) with or without hormonochemotherapy, external and interstitial radiotherapy, and consolidation chemotherapy with or without hormonochemotherapy. Tumor regression over 50% was observed in 91% patients after chemotherapy, and complete clinical remission occurred in 100% patients after irradiation. The rate of local relapse is 13%. The 3-year disease-free survival is 62% and 3-year global survival is 77%. Initial chemotherapeutic tumor regression greater than 75% is the main predictive factor for disease-free survival.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0008-543X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
15
|
pubmed:volume |
61
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
N
|
pubmed:pagination |
1977-82
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3129176-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:3129176-Brachytherapy,
pubmed-meshheading:3129176-Breast Neoplasms,
pubmed-meshheading:3129176-Cobalt Radioisotopes,
pubmed-meshheading:3129176-Combined Modality Therapy,
pubmed-meshheading:3129176-Doxorubicin,
pubmed-meshheading:3129176-Evaluation Studies as Topic,
pubmed-meshheading:3129176-Fluorouracil,
pubmed-meshheading:3129176-Humans,
pubmed-meshheading:3129176-Iridium Radioisotopes,
pubmed-meshheading:3129176-Methotrexate,
pubmed-meshheading:3129176-Prednisone,
pubmed-meshheading:3129176-Radioisotope Teletherapy,
pubmed-meshheading:3129176-Remission Induction,
pubmed-meshheading:3129176-Tamoxifen,
pubmed-meshheading:3129176-Thiotepa,
pubmed-meshheading:3129176-Vinblastine
|
pubmed:year |
1988
|
pubmed:articleTitle |
Results of a conservative treatment combining induction (neoadjuvant) and consolidation chemotherapy, hormonotherapy, and external and interstitial irradiation in 98 patients with locally advanced breast cancer (IIIA-IIIB).
|
pubmed:affiliation |
Service d'Oncologie Médicale, Hopital de la Salpétrière, Paris, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|