Linked Life Data

3120414

Source:http://linkedlifedata.com/resource/pubmed/id/3120414

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-1-21
pubmed:abstractText
The prophylactic effect of anti-D in the prevention of maternal immunization to the D antigen of the Rh system depends in the first instance on its ability to bind to fetal Rh-positive red cells. The functional activity of the injected anti-D in this respect is dependent on both the plasma concentration and functional affinity constant of the antibody, and both factors should be taken into account in assessing IgG anti-D preparations for clinical use. A radio-immunoassay utilizing 125-I-labelled human monoclonal anti-D has been developed which measures the amount of antibody bound to red cells after the addition of an aliquot of the test anti-D preparation. The assay is thus a functional test in that it measures the ability of the anti-D to react with the antigen. The functional activity of the test anti-D is compared to that of the international standard, and the concentration is then expressed in terms of microgram-equivalents, that is, its equivalence in functional terms to the stated amount of international standard. The radio-immunoassay was compared to the currently used agglutination assay, and the results were found to give good agreement in 18 out of the 21 samples assayed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0042-9007
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
175-80
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Radio-immunoassay of the functional activity of anti-D (Rh) preparations using a human monoclonal 125I-labelled anti-D.
pubmed:affiliation
MRC Mechanisms in Tumour Immunity, MRC Centre, Cambridge, UK.
pubmed:publicationType
Journal Article