Linked Life Data

3117746

Source:http://linkedlifedata.com/resource/pubmed/id/3117746

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1987-12-11
pubmed:abstractText
The effect of 5 beta-chol-3-en-24-oic acid (delta 3) on N-methyl-N-nitrosourea (MNU)-induced colonic tumorigenesis was studied by intrarectal injection of these compounds in rats. Female Fischer rats received 0.5 ml of distilled water (DW) alone or DW containing 2.5 mg of MNU twice in one week followed by 0.5 ml of peanut oil (PO) alone or PO containing 1 mg of delta 3, or 1 mg of lithocholic acid (LC) thrice weekly for 48 weeks. Thus, 6 groups were employed as follows: group I, DW + PO (n = 12); group II, DW + delta 3 (n = 30); group III, DW + LC (n = 30); group IV, MNU + PO (n = 30); group V, MNU + delta 3 (n = 30) and group VI, MNU + LC (n = 37). Fecal bile acid profiles were analyzed before and during the treatment. Numbers of rats bearing colonic tumor were none in the groups without MNU, but 5 (17%) in group IV, 15 (50%) in group V and 12 (32%) in group VI (corrected X2 = 6.07, P less than 0.025 for group IV vs V, and 1.42, P less than 0.3 for group IV vs VI). Total numbers of tumors were 7, 17 and 15 in group IV, V and VI, respectively, and they were mostly adenomas and adenocarcinomas. A breast fibroadenoma in one rat of group VI was the sole extracolonic neoplasm in these rats. Total fecal bile acids ranged from 7.7 to 10.5 mumol/g dry feces during the study without any significant quantitative or qualitative difference with respect to with or without bile acids and MNU treatment. These results indicated that delta 3 promoted MNU-induced colonic tumorigenesis in rats without alteration in bile acid metabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0910-5050
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
908-14
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Promoting effect of 5 beta-chol-3-en-24-oic acid on N-methyl-N-nitrosourea-induced colonic tumorigenesis in rats.
pubmed:affiliation
Department of Internal Medicine, Hyogo College of Medicine.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't