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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1987-9-21
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pubmed:abstractText |
A murine T cell clone, 24-2C, responds specifically to human IgG (HGG) in the context of I-Ab. B cells purified from mouse spleen cells were examined for their function as antigen-presenting cells (APC) in the response of 24-2C cells to HGG. B cells functioned as APC for IL-2 production but not for proliferation, whereas spleen cells or spleen-adherent cells functioned as APC for both IL-2 production and proliferation. LPS-activated B cells also failed to induce the proliferative response. The addition of the culture supernatant of 24-2C cells stimulated with HGG presented by irradiated spleen cells to the culture of 24-2C cells, irradiated B cells, and HGG induced the proliferative response of 24-2C cells, whereas IL-1, IL-3, and/or interferon-gamma did not reconstitute the proliferation. The expression of IL-2 receptors (IL-2R) on 24-2C cells was examined using a monoclonal anti-mouse IL-2R antibody AMT 13 or 7D4. 24-2C cells cultured with spleen cells as APC expressed IL-2R. Those cultured alone or with B cells as APC did not express IL-2R. Enlargement of 24-2C cells in response to HGG was also examined, and the relative cell size of those cultured with B cells or spleen cells as APC was larger than that of those cultured alone. These results demonstrate that B cells as APC induce IL-2 production and cell size enlargement in the response of 24-2C cloned T cells to HGG, but not IL-2R expression nor proliferation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0008-8749
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
150-61
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3111723-Animals,
pubmed-meshheading:3111723-Antigen-Presenting Cells,
pubmed-meshheading:3111723-B-Lymphocytes,
pubmed-meshheading:3111723-Cell Division,
pubmed-meshheading:3111723-Clone Cells,
pubmed-meshheading:3111723-Gene Expression Regulation,
pubmed-meshheading:3111723-Immunoglobulin G,
pubmed-meshheading:3111723-Interleukin-2,
pubmed-meshheading:3111723-Lipopolysaccharides,
pubmed-meshheading:3111723-Lymphocyte Activation,
pubmed-meshheading:3111723-Mice,
pubmed-meshheading:3111723-Mice, Inbred C57BL,
pubmed-meshheading:3111723-Receptors, Immunologic,
pubmed-meshheading:3111723-Receptors, Interleukin-2,
pubmed-meshheading:3111723-Spleen,
pubmed-meshheading:3111723-T-Lymphocytes
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pubmed:year |
1987
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pubmed:articleTitle |
B cells as antigen-presenting cells: antigen-specific IL-2 production by cloned T cells without expression of IL-2 receptors.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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