| pubmed-article:3109392 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3109392 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:3109392 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:3109392 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:3109392 | lifeskim:mentions | umls-concept:C0002260 | lld:lifeskim |
| pubmed-article:3109392 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3109392 | lifeskim:mentions | umls-concept:C0376452 | lld:lifeskim |
| pubmed-article:3109392 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:3109392 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3109392 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:3109392 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:3109392 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3109392 | pubmed:dateCreated | 1987-7-17 | lld:pubmed |
| pubmed-article:3109392 | pubmed:abstractText | Murine erythroleukaemic (MEL) cells cultured with alpha-difluoromethylornithine (DFMO) accumulated decarboxylated S-adenosylmethionine(decarboxylated AdoMet). In the absence of the inducer hexamethylenebisacetamide (HMBA), this accumulation of decarboxylated AdoMet was associated with a concomitant and proportional increase in DNA hypomethylation. In the presence of HMBA, DFMO, which stimulates the erythrodifferentiation of MEL cells, enhanced the differentiation-associated DNA hypomethylation. However, this differentiation-associated DNA hypomethylation was neither temporally nor quantitatively correlated with the accumulation of decarboxylated AdoMet in these cells. Therefore DFMO probably stimulates the HMBA-induced differentiation of MEL cells and the associated DNA hypomethylation via the effect of this drug on polyamine biosynthesis. | lld:pubmed |
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| pubmed-article:3109392 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3109392 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3109392 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3109392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3109392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3109392 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3109392 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3109392 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:3109392 | pubmed:author | pubmed-author:OsborneH BHB | lld:pubmed |
| pubmed-article:3109392 | pubmed:author | pubmed-author:PapazafiriPP | lld:pubmed |
| pubmed-article:3109392 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3109392 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3109392 | pubmed:volume | 242 | lld:pubmed |
| pubmed-article:3109392 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3109392 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3109392 | pubmed:pagination | 479-83 | lld:pubmed |
| pubmed-article:3109392 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3109392 | pubmed:meshHeading | pubmed-meshheading:3109392-... | lld:pubmed |
| pubmed-article:3109392 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3109392 | pubmed:articleTitle | Effect of alpha-difluoromethylornithine on DNA methylation in murine erythroleukaemic cells. Relationship to stimulation of induced differentiation. | lld:pubmed |
| pubmed-article:3109392 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3109392 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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