| pubmed-article:3106964 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3106964 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:3106964 | lifeskim:mentions | umls-concept:C0018555 | lld:lifeskim |
| pubmed-article:3106964 | lifeskim:mentions | umls-concept:C0376622 | lld:lifeskim |
| pubmed-article:3106964 | lifeskim:mentions | umls-concept:C0061421 | lld:lifeskim |
| pubmed-article:3106964 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:3106964 | pubmed:dateCreated | 1987-6-18 | lld:pubmed |
| pubmed-article:3106964 | pubmed:abstractText | The glucose-regulated protein (GRP) system in mammalian cells is induced by glucose deprivation, anoxia, the calcium ionophore A23187, and 2-deoxyglucose. In Chinese hamster ovary cells the major GRPs are approximately equal to 76, 97, and 170 kDa. Removal of each of these four GRP-inducing stresses leads to the coordinate repression of GRPs and induction of the major heat shock proteins at 70 and 89 kDa. The application of each of these four GRP-inducing conditions leads to a significant induction of resistance to the drug doxorubicin. Removal of each GRP-inducing condition results in the rapid disappearance of this resistance in a manner that correlates with the repression of the GRPs. The retention of doxorubicin by GRP-induced cells does not explain the induced drug resistance. When the RIF in vitro/in vivo tumor system is probed with an antibody against the 76-kDa GRP, a significant increase in this GRP is observed in cells obtained from the central regions of tumors. Since hypoxia and/or nutrient deprivation can occur during tumor development, a GRP-induced state in the tumor may confer resistance to doxorubicin treatment. | lld:pubmed |
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| pubmed-article:3106964 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3106964 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3106964 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3106964 | pubmed:month | May | lld:pubmed |
| pubmed-article:3106964 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3106964 | pubmed:author | pubmed-author:GessnerTT | lld:pubmed |
| pubmed-article:3106964 | pubmed:author | pubmed-author:ChaoCC | lld:pubmed |
| pubmed-article:3106964 | pubmed:author | pubmed-author:HughesCC | lld:pubmed |
| pubmed-article:3106964 | pubmed:author | pubmed-author:SheaEE | lld:pubmed |
| pubmed-article:3106964 | pubmed:author | pubmed-author:BartelsCC | lld:pubmed |
| pubmed-article:3106964 | pubmed:author | pubmed-author:CaoPP | lld:pubmed |
| pubmed-article:3106964 | pubmed:author | pubmed-author:SubjeckJJ | lld:pubmed |
| pubmed-article:3106964 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3106964 | pubmed:volume | 84 | lld:pubmed |
| pubmed-article:3106964 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3106964 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3106964 | pubmed:pagination | 3278-82 | lld:pubmed |
| pubmed-article:3106964 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3106964 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3106964 | pubmed:articleTitle | Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells. | lld:pubmed |
| pubmed-article:3106964 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3106964 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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