Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1987-6-18
pubmed:abstractText
The glucose-regulated protein (GRP) system in mammalian cells is induced by glucose deprivation, anoxia, the calcium ionophore A23187, and 2-deoxyglucose. In Chinese hamster ovary cells the major GRPs are approximately equal to 76, 97, and 170 kDa. Removal of each of these four GRP-inducing stresses leads to the coordinate repression of GRPs and induction of the major heat shock proteins at 70 and 89 kDa. The application of each of these four GRP-inducing conditions leads to a significant induction of resistance to the drug doxorubicin. Removal of each GRP-inducing condition results in the rapid disappearance of this resistance in a manner that correlates with the repression of the GRPs. The retention of doxorubicin by GRP-induced cells does not explain the induced drug resistance. When the RIF in vitro/in vivo tumor system is probed with an antibody against the 76-kDa GRP, a significant increase in this GRP is observed in cells obtained from the central regions of tumors. Since hypoxia and/or nutrient deprivation can occur during tumor development, a GRP-induced state in the tumor may confer resistance to doxorubicin treatment.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-196769, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-198809, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-216013, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-2421411, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-3510555, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-3708583, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-3714978, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-3865213, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-3944208, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-4038625, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-481423, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-5942772, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-6146362, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-6208814, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-6355118, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-6406494, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-6574828, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-6589630, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-6611857, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-6630181, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-6928244, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-6928245, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-7061256, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-7074623, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-7104992, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-7116088, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-7199521, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-7272189, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-7437289, http://linkedlifedata.com/resource/pubmed/commentcorrection/3106964-7459222
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
84
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3278-82
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Coinduction of glucose-regulated proteins and doxorubicin resistance in Chinese hamster cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.