Linked Life Data

3106724

Source:http://linkedlifedata.com/resource/pubmed/id/3106724

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-6-12
pubmed:abstractText
Patching small intestinal defects with colon serosa results in the growth of functional neomucosa. However, the rate of neomucosal growth is slow and the defect contracts markedly. The aim of this study was to determine if systemic urogastrone would enhance neomucosal growth. Twenty-two New Zealand white rabbits had two 2 X 5-cm ileal defects patched with colon serosa and osmotic pumps placed subcutaneously. Eleven animals had saline infused at a rate of 5 microliter/hr. The other eleven rabbits had urogastrone (1 mg/ml saline) infused at the same rate. One animal died in this group. There was a modest increase in neomucosal growth after 2 weeks of urogastrone infusion. Three weeks after patching, defect coverage was significantly greater in the urogastrone group (99.8 +/- 0.1 vs 96.0 +/- 1.2%, P less than 0.005) and more defects were completely covered by neomucosa (6/10 vs 1/12, P less than 0.05). Less contraction occurred in the urogastrone group (46 +/- 2 vs 35 +/- 3% initial defect, P less than 0.005) and resultant neomucosal surface area was greater (361 +/- 12 vs 266 +/- 20 mm2, P less than 0.0005). In vitro glucose uptake was significantly greater in the urogastrone group but disaccharidase and diamine oxidase activity were similar. Crypt cell production rate was significantly greater 2 weeks after operation compared to 3 weeks in both groups and was greater in the urogastrone group compared to the saline group at 2 weeks (24.9 +/- 1.1 vs 20.1 +/- 1.1, P less than 0.02). Systemic urogastrone enhances neomucosal growth by increasing the rate of growth and diminishing contraction.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
402-10
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Stimulation of neomucosal growth by systemic urogastrone.
pubmed:publicationType
Journal Article