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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6101
|
| pubmed:dateCreated |
1987-2-26
|
| pubmed:abstractText |
Interleukin-2 (IL-2), originally described as a growth factor required for sustained proliferation of T cells in vitro is a glycoprotein hormone of known structure which appears to be important for the generation of immune responses in vivo. As well as T lymphocytes, B lymphocytes and large granular lymphocytes with natural killer activity (NK cells) can also respond to IL-2. The action of IL-2 seemed to be limited specifically to lymphocytes, however, and the term 'T-lymphocytotrophic hormone' was used. Here we provide evidence that human monocytes display a substantially increased cytotoxic activity as a direct and rapid response to human recombinant IL-2 but not to human recombinant glycosylated interferon-gamma (IFN-gamma) or lipopolysaccharide. Our results reveal a previously unknown function of IL-2 and suggest its possible involvement in monocyte-T cell interactions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0028-0836
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
325
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
262-5
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3100957-Cell Division,
pubmed-meshheading:3100957-Cytotoxicity, Immunologic,
pubmed-meshheading:3100957-Humans,
pubmed-meshheading:3100957-Interferon-gamma,
pubmed-meshheading:3100957-Interleukin-2,
pubmed-meshheading:3100957-Lipopolysaccharides,
pubmed-meshheading:3100957-Monocytes,
pubmed-meshheading:3100957-Recombinant Proteins
|
| pubmed:articleTitle |
Recombinant interleukin-2 directly augments the cytotoxicity of human monocytes.
|
| pubmed:publicationType |
Journal Article
|