| pubmed-article:3100615 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C0024320 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C0018183 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C0021745 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C0034805 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:3100615 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:3100615 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3100615 | pubmed:dateCreated | 1987-3-2 | lld:pubmed |
| pubmed-article:3100615 | pubmed:abstractText | We report here a comparative study of the effects of several cytokines known to affect myeloid cell differentiation on functional properties of human mature granulocytes. We show that recombinant interferon-gamma (rIFN-gamma), recombinant granulocyte/macrophage-colony stimulating factor (rGM-CSF), recombinant tumor necrosis factor (rTNF), and lymphotoxin (LT) purified to homogeneity are potent stimulators of polymorphonuclear cells (PMN) activity. All cytokines enhance antibody-dependent cell-mediated cytotoxicity (Ab-CMC) mediated by human PMN; however, rGM-CSF, rTNF, and LT have an immediate and short-lived effect on the PMN, whereas the activation by rIFN-gamma requires several hours of induction but can be observed up to 24 to 48 hr of culture. Only the effect of rIFN-gamma is in part dependent on induction of a high-affinity FcR for monomeric IgG on PMN, as suggested by two-color sorting analysis, and on mechanisms that result in prolonged survival of PMN in a functionally active state to mediate oxidative burst, phagocytosis, and bactericidal activity. Greater enhancement of Ab-CMC is obtained by using rIFN-gamma in combination with the other cytokines. Our data indicate that cytokines previously defined on the basis of their cytotoxic effects mediate a wide spectrum of activities on mature myeloid cells and provide evidence for their possible role in vivo, alone or in combination with rIFN-gamma, in modulating functional activities of cells responsible for non-adaptive systems of defense. | lld:pubmed |
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| pubmed-article:3100615 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3100615 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:3100615 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3100615 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3100615 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:3100615 | pubmed:author | pubmed-author:KobayashiMM | lld:pubmed |
| pubmed-article:3100615 | pubmed:author | pubmed-author:TrinchieriGG | lld:pubmed |
| pubmed-article:3100615 | pubmed:author | pubmed-author:PerussiaBB | lld:pubmed |
| pubmed-article:3100615 | pubmed:author | pubmed-author:RossiM EME | lld:pubmed |
| pubmed-article:3100615 | pubmed:author | pubmed-author:AnegonII | lld:pubmed |
| pubmed-article:3100615 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3100615 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:3100615 | pubmed:volume | 138 | lld:pubmed |
| pubmed-article:3100615 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3100615 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3100615 | pubmed:pagination | 765-74 | lld:pubmed |
| pubmed-article:3100615 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:3100615 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3100615 | pubmed:articleTitle | Immune interferon enhances functional properties of human granulocytes: role of Fc receptors and effect of lymphotoxin, tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor. | lld:pubmed |
| pubmed-article:3100615 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3100615 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3100615 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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