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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1987-2-6
|
| pubmed:abstractText |
Renal insufficiency is the most frequent complication of malignant hypertension (MHT). The initiation of effective hypotensive treatment is generally followed by a rapid improvement of renal functions, but the long-term evolution has been only rarely studied. A group of 30 patients was retrospectively selected on the following criteria: Malignant hypertension: mean DBP 138 +/- 20 mmHg, hypertensive retinopathy stage III-IV; Early renal insufficiency: mean Inulin clearance (CIN) 66 +/- 26 ml/min, mean PAH clearance (CPAH) 364 +/- 161 ml/min; Clinical and functional follow-up ranging from 5 to 18 years. Among these patients, two groups were defined according to the quality of BP control: good or fair responders (GR) with a DBP always less than 110 mmHg, poor responders (PR) with a DBP occasionally greater than or equal to 110 mmHg. The results show in the two groups an improvement of CIN at 3 years, followed by a stabilization then a decrease after the 6th year. However the early improvement is significantly lower in PR. Despite similar initial values (GR = 54.7 +/- 31.3; PR = 51.4 +/- 13.2), CIN remains always lower in PR (at 9 years = GR 72.4 +/- 30.6; PR 56.0 +/- 19.8). During the first 3 years, CPAH increases in GR, whereas it decreases in PR, resulting in significantly different values at 3 years. At 9 years, CPAH remains improved in GR (329.1 +/- 109.3 vs 281.7 +/- 173.8 initially) but decreased in PR (256.0 +/- 166.9 vs 307.3 +/- 119.5 initially). The parallel improvement of CIN and CPAH in GR confirms a favorable effect of BP control on early vascular lesions.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
fre
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0003-9683
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
79
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
767-72
|
| pubmed:dateRevised |
2009-2-13
|
| pubmed:meshHeading |
pubmed-meshheading:3099691-Adult,
pubmed-meshheading:3099691-Antihypertensive Agents,
pubmed-meshheading:3099691-Drug Therapy, Combination,
pubmed-meshheading:3099691-Female,
pubmed-meshheading:3099691-Follow-Up Studies,
pubmed-meshheading:3099691-Glomerular Filtration Rate,
pubmed-meshheading:3099691-Humans,
pubmed-meshheading:3099691-Hypertension, Malignant,
pubmed-meshheading:3099691-Inulin,
pubmed-meshheading:3099691-Kidney,
pubmed-meshheading:3099691-Male,
pubmed-meshheading:3099691-Middle Aged,
pubmed-meshheading:3099691-p-Aminohippuric Acid
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
[Course of renal function in malignant hypertension. Effect of treatment. Study of 30 cases followed for 5 to 18 years].
|
| pubmed:publicationType |
Journal Article,
English Abstract
|