| pubmed-article:3099392 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3099392 | lifeskim:mentions | umls-concept:C0038661 | lld:lifeskim |
| pubmed-article:3099392 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3099392 | lifeskim:mentions | umls-concept:C0031268 | lld:lifeskim |
| pubmed-article:3099392 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:3099392 | lifeskim:mentions | umls-concept:C0026455 | lld:lifeskim |
| pubmed-article:3099392 | lifeskim:mentions | umls-concept:C0032743 | lld:lifeskim |
| pubmed-article:3099392 | lifeskim:mentions | umls-concept:C1283195 | lld:lifeskim |
| pubmed-article:3099392 | pubmed:issue | 4787 | lld:pubmed |
| pubmed-article:3099392 | pubmed:dateCreated | 1987-2-19 | lld:pubmed |
| pubmed-article:3099392 | pubmed:abstractText | The regional distributions of monoamine oxidase (MAO) types A and B have been identified in human brain in vivo with intravenously injected 11C-labeled suicide enzyme inactivators, clorgyline and L-deprenyl, and positron emission tomography. The rapid brain uptake and retention of radioactivity for both 11C tracers indicated irreversible trapping. The anatomical distribution of 11C paralleled the distribution of MAO A and MAO B in human brain in autopsy material. The corpus striatum, thalamus, and brainstem contained high MAO activity. The magnitudes of uptake of both [11C]clorgyline and L-[11C]deprenyl were markedly reduced in one subject treated with the antidepressant MAO inhibitor phenelzine. A comparison of the brain uptake and retention of the 11C-labeled inactive (D-) and active (L-) enantiomers of deprenyl showed rapid clearance of the inactive enantiomer and retention of the active enantiomer within MAO B-rich brain structures, in agreement with the known stereoselectivity of MAO B for L-deprenyl. Prior treatment with unlabeled L-deprenyl prevented retention of L-[11C]deprenyl. Thus, suicide enzyme inactivators labeled with positron emitters can be used to quantitate the distribution and kinetic characteristics of MAO in human brain structures. | lld:pubmed |
| pubmed-article:3099392 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3099392 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3099392 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3099392 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3099392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3099392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3099392 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3099392 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3099392 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3099392 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:3099392 | pubmed:author | pubmed-author:ArnettC DCD | lld:pubmed |
| pubmed-article:3099392 | pubmed:author | pubmed-author:SmithMM | lld:pubmed |
| pubmed-article:3099392 | pubmed:author | pubmed-author:MacGregorR... | lld:pubmed |
| pubmed-article:3099392 | pubmed:author | pubmed-author:FowlerJ SJS | lld:pubmed |
| pubmed-article:3099392 | pubmed:author | pubmed-author:SachsHH | lld:pubmed |
| pubmed-article:3099392 | pubmed:author | pubmed-author:WolfA PAP | lld:pubmed |
| pubmed-article:3099392 | pubmed:author | pubmed-author:LoganJJ | lld:pubmed |
| pubmed-article:3099392 | pubmed:author | pubmed-author:ChristmanDD | lld:pubmed |
| pubmed-article:3099392 | pubmed:author | pubmed-author:DeweyS LSL | lld:pubmed |
| pubmed-article:3099392 | pubmed:author | pubmed-author:SchlyerDD | lld:pubmed |
| pubmed-article:3099392 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3099392 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:3099392 | pubmed:volume | 235 | lld:pubmed |
| pubmed-article:3099392 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3099392 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:3099392 | pubmed:pagination | 481-5 | lld:pubmed |
| pubmed-article:3099392 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:3099392 | pubmed:meshHeading | pubmed-meshheading:3099392-... | lld:pubmed |
| pubmed-article:3099392 | pubmed:meshHeading | pubmed-meshheading:3099392-... | lld:pubmed |
| pubmed-article:3099392 | pubmed:meshHeading | pubmed-meshheading:3099392-... | lld:pubmed |
| pubmed-article:3099392 | pubmed:meshHeading | pubmed-meshheading:3099392-... | lld:pubmed |
| pubmed-article:3099392 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3099392 | pubmed:articleTitle | Mapping human brain monoamine oxidase A and B with 11C-labeled suicide inactivators and PET. | lld:pubmed |
| pubmed-article:3099392 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3099392 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3099392 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3099392 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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