| pubmed-article:3097059 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:3097059 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
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| pubmed-article:3097059 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
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| pubmed-article:3097059 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:3097059 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3097059 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:3097059 | lifeskim:mentions | umls-concept:C0597879 | lld:lifeskim |
| pubmed-article:3097059 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:3097059 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:3097059 | lifeskim:mentions | umls-concept:C0332240 | lld:lifeskim |
| pubmed-article:3097059 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:3097059 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3097059 | pubmed:dateCreated | 1987-1-16 | lld:pubmed |
| pubmed-article:3097059 | pubmed:abstractText | Using a specific and sensitive RIA for GH-releasing hormone (GHRH), we examined the effect of oral administration of 75 g glucose on peripheral plasma GHRH-like immunoreactivity (GHRH-LI) in normal subjects (n = 12) and patients with idiopathic GH deficiency (IGHD) (n = 6). The normal subjects had two peaks of plasma GHRH-LI after oral glucose administration. The initial peak GHRH-LI levels occurred 30-150 min after glucose ingestion and corresponded to an increase in blood glucose. The increment in plasma GHRH-LI levels 30 min after glucose ingestion [7.4 +/- 2.4 (+/- SEM) pg/ml] was significantly higher (P less than 0.05) than that during a control study. Second peaks in plasma GHRH-LI occurred 3.5-6 h after glucose ingestion, and the mean increment 5 h after glucose ingestion was 9.4 +/- 2.4 pg/ml. This second rise of plasma GHRH-LI coincided with a significant increase in plasma GH after reactive hypoglycemia. This second GHRH-LI peak and the rise of plasma GH after hypoglycemia were absent in patients with IGHD, whereas the first peak of plasma GHRH-LI appeared shortly after glucose ingestion in these patients as well as in normal subjects. In addition, hypoglycemia produced by iv injection of regular insulin (0.1 U/kg) was not accompanied by increases in plasma GHRH-LI and GH levels in patients with IGHD, whereas insulin-induced hypoglycemia resulted in significant elevations of both plasma GHRH-LI and GH levels in normal subjects. These findings suggest that peripheral plasma GHRH-LI is derived from the hypothalamus as well as from an extrahypothalamic source(s); extrahypothalamic GHRH is released shortly after glucose ingestion; and secretion of GHRH from the hypothalamus is stimulated by hypoglycemia. | lld:pubmed |
| pubmed-article:3097059 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3097059 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3097059 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3097059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3097059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3097059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3097059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3097059 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3097059 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3097059 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3097059 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:3097059 | pubmed:author | pubmed-author:SatoMM | lld:pubmed |
| pubmed-article:3097059 | pubmed:author | pubmed-author:FujitaTT | lld:pubmed |
| pubmed-article:3097059 | pubmed:author | pubmed-author:ChiharaKK | lld:pubmed |
| pubmed-article:3097059 | pubmed:author | pubmed-author:KitaTT | lld:pubmed |
| pubmed-article:3097059 | pubmed:author | pubmed-author:KashiiCC | lld:pubmed |
| pubmed-article:3097059 | pubmed:author | pubmed-author:KadowakiSS | lld:pubmed |
| pubmed-article:3097059 | pubmed:author | pubmed-author:OkimuraYY | lld:pubmed |
| pubmed-article:3097059 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3097059 | pubmed:volume | 64 | lld:pubmed |
| pubmed-article:3097059 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3097059 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3097059 | pubmed:pagination | 92-7 | lld:pubmed |
| pubmed-article:3097059 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:3097059 | pubmed:meshHeading | pubmed-meshheading:3097059-... | lld:pubmed |
| pubmed-article:3097059 | pubmed:meshHeading | pubmed-meshheading:3097059-... | lld:pubmed |
| pubmed-article:3097059 | pubmed:meshHeading | pubmed-meshheading:3097059-... | lld:pubmed |
| pubmed-article:3097059 | pubmed:meshHeading | pubmed-meshheading:3097059-... | lld:pubmed |
| pubmed-article:3097059 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3097059 | pubmed:articleTitle | Effect of oral glucose administration on plasma growth hormone-releasing hormone (GHRH)-like immunoreactivity levels in normal subjects and patients with idiopathic GH deficiency: evidence that GHRH is released not only from the hypothalamus but also from extrahypothalamic tissue. | lld:pubmed |
| pubmed-article:3097059 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3097059 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3097059 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3097059 | lld:pubmed |
