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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1986-12-24
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pubmed:abstractText |
Calcium regulates parathyroid secretion through mechanisms yet to be elucidated. We have investigated this phenomenon through use of pertussis toxin which catalyzes ADP-ribosylation and inactivation of a guanine nucleotide regulatory protein, possibly Ni or No. Calcium inhibition of PTH release is blocked in cells treated with pertussis toxin, and there is concomitant ADP-ribosylation of a 40-kilodalton protein. The ionophore A23187 inhibits secretion in toxin-treated as well as in control cells. We conclude that a guanine nucleotide regulatory protein is involved in calcium regulation of PTH secretion at a locus proximal to the intracellular site effecting inhibition of secretion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0013-7227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2700-3
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3096694-Adenosine Diphosphate Ribose,
pubmed-meshheading:3096694-Animals,
pubmed-meshheading:3096694-Calcimycin,
pubmed-meshheading:3096694-Calcium,
pubmed-meshheading:3096694-Cattle,
pubmed-meshheading:3096694-Cell Membrane,
pubmed-meshheading:3096694-Cells, Cultured,
pubmed-meshheading:3096694-GTP-Binding Proteins,
pubmed-meshheading:3096694-Parathyroid Glands,
pubmed-meshheading:3096694-Parathyroid Hormone,
pubmed-meshheading:3096694-Pertussis Toxin,
pubmed-meshheading:3096694-Secretory Rate,
pubmed-meshheading:3096694-Virulence Factors, Bordetella
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pubmed:year |
1986
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pubmed:articleTitle |
Calcium-controlled secretion is effected through a guanine nucleotide regulatory protein in parathyroid cells.
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pubmed:publicationType |
Journal Article
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