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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-12-3
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pubmed:abstractText |
A conjugate, composed of the cell wall polysaccharide (C polysaccharide) of Streptococcus pneumoniae and bovine serum albumin (BSA), was prepared with the bifunctional agent N-succinimidyl-3-(2-pyridyldithio)-propionate. Analysis with monoclonal antibodies provided evidence that the phosphocholine (PC) moiety of the C polysaccharide was retained during the conjugation procedure. The C polysaccharide-BSA conjugate elicited antibodies to C polysaccharide in rabbits; no PC-specific antibodies were detected in globulins prepared from these hyperimmune sera obtained early and late after a second immunization. Rabbit hyperimmune sera were taken after multiple intravenous injections of the pneumococcus strain SRC-2, which has a capsulelike structure composed of the C polysaccharide. Globulin prepared from these antisera had both C polysaccharide- and PC-specific antibodies. Antibodies to C polysaccharide elicited by the C polysaccharide-BSA conjugate failed to protect mice against intraperitoneal challenge with a strain of type 3 or type 6A pneumococci. The anti-SRC-2 globulin conferred protection against both of these pneumococcal strains. Absorption of the SRC-2 globulin with C polysaccharide, however, failed to change its protective activity. These data provide evidence that antibodies to the C polysaccharide do not confer immunity against infection of mice with encapsulated pneumococci inoculated by the intraperitoneal route.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-13650640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-14023808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-2412271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-28483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-3874879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-4056007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-4103271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-4162604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-4185041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-4380916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-4386878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-4633975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-5316354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6084398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6170000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6184399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6199306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6361173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6381634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6437983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6601061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6766973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6832828,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6840851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6854020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6974386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-6995835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-7025155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-7076292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-708370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-7109171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-7153709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-7170960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-7216442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-7216443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-7299351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-7426624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3095243-81259
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
448-55
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3095243-Animals,
pubmed-meshheading:3095243-Antibodies, Bacterial,
pubmed-meshheading:3095243-Cell Wall,
pubmed-meshheading:3095243-Immunity, Active,
pubmed-meshheading:3095243-Immunodiffusion,
pubmed-meshheading:3095243-Mice,
pubmed-meshheading:3095243-Pneumococcal Infections,
pubmed-meshheading:3095243-Polysaccharides, Bacterial,
pubmed-meshheading:3095243-Rabbits
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pubmed:year |
1986
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pubmed:articleTitle |
Rabbit antibodies to the cell wall polysaccharide of Streptococcus pneumoniae fail to protect mice from lethal challenge with encapsulated pneumococci.
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pubmed:publicationType |
Journal Article
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