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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1986-8-1
|
| pubmed:abstractText |
Fifty-seven patients with bacterial meningitis were treated with once daily ceftriaxone. After an initial loading dose of 100 mg/kg, the patients received 80 mg/kg as a single daily dose. Etiologic agents included: Haemophilus influenzae type b, 37 (11 beta-lactamase-positive); Neisseria meningitidis, 11; Streptococcus pneumoniae, 6; Streptococcus pyogenes, 1; Haemophilus influenzae type f, 1; and Group B Streptococcus, 1. All patients showed clinical improvement and all were bacteriologically cured. Satisfactory cerebrospinal fluid bactericidal activity and drug concentrations were seen 24 hours after a dose even in those patients in whom repeat spinal taps were carried out following the last dose of therapy. The drug was well-tolerated and the major adverse effect seen was diarrhea in 20.4% of the patients. The diarrhea was mild and self-limited and did not necessitate discontinuation of the drug although it was frequently associated with alterations in the stool microbiologic flora. Based on this preliminary experience, ceftriaxone, when given in a single daily dose, appears safe and effective in the treatment of bacterial meningitis in nonneonatal infants and children.
|
| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0277-9730
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
293-7
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:3088548-Bacterial Infections,
pubmed-meshheading:3088548-Ceftriaxone,
pubmed-meshheading:3088548-Child,
pubmed-meshheading:3088548-Child, Preschool,
pubmed-meshheading:3088548-Diarrhea,
pubmed-meshheading:3088548-Feces,
pubmed-meshheading:3088548-Female,
pubmed-meshheading:3088548-Haemophilus influenzae,
pubmed-meshheading:3088548-Humans,
pubmed-meshheading:3088548-Infant,
pubmed-meshheading:3088548-Infant, Newborn,
pubmed-meshheading:3088548-Male,
pubmed-meshheading:3088548-Meningitis,
pubmed-meshheading:3088548-Meningitis, Haemophilus,
pubmed-meshheading:3088548-Meningitis, Meningococcal,
pubmed-meshheading:3088548-Meningitis, Pneumococcal,
pubmed-meshheading:3088548-Neisseria meningitidis,
pubmed-meshheading:3088548-Streptococcus agalactiae,
pubmed-meshheading:3088548-Streptococcus pneumoniae,
pubmed-meshheading:3088548-Streptococcus pyogenes
|
| pubmed:articleTitle |
Safety and efficacy of once daily ceftriaxone for the treatment of bacterial meningitis.
|
| pubmed:publicationType |
Journal Article
|