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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-7-7
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pubmed:abstractText |
Lung defenses against Pseudomonas aeruginosa were investigated in C5-deficient strains of mice with different genetic backgrounds. We studied pulmonary clearance and cell responses after aerosol exposure to P. aeruginosa in C5-deficient B10.D2/oSnJ and DBA/2J mice and their closest C5-sufficient counterparts, B10.D2/nSnJ and DBA/1J mice. Different patterns of lung clearance and pulmonary cell responses were found for the two C5-deficient strains. C5-deficient B10.D2/oSnJ mice showed defective lung clearance of P. aeruginosa 4 h after challenge compared with C5-sufficient B10.D2/nSnJ animals. This finding was associated with a decreased number of polymorphonuclear leukocytes recruited into the airways during the same time. Interestingly, C5-deficient DBA/2J mice recruited higher numbers of polymorphonuclear leukocytes than did C5-sufficient DBA/1J mice by 4 h after aerosolization. Nevertheless, lung clearance of P. aeruginosa in DBA/2J mice was not as effective as in C5-sufficient DBA/1J mice, suggesting that other functions of C5 besides chemotaxism could be involved. Lung clearance of P. aeruginosa was also investigated in C5-deficient and -sufficient hybrids sharing the same genetic background (DBA/2J X B10.D2). The results suggested that murine lung clearance of P. aeruginosa is markedly affected by lack of C5 in a specific genetic background (B10.D2).
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-109545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-27534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-335934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-337041,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-358800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-3884520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-3920067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-3926643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-4201225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-4384494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-492335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-4959665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-619716,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-6266014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-6350178,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-6363279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-6404822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-6573117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-6809882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-6830054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-6995480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-7081809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-7086356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-7103255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-7382721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3086235-932197
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
853-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3086235-Aerosols,
pubmed-meshheading:3086235-Animals,
pubmed-meshheading:3086235-Complement C5,
pubmed-meshheading:3086235-Immunity, Cellular,
pubmed-meshheading:3086235-Lung,
pubmed-meshheading:3086235-Mice,
pubmed-meshheading:3086235-Mice, Inbred Strains,
pubmed-meshheading:3086235-Neutrophils,
pubmed-meshheading:3086235-Phagocytes,
pubmed-meshheading:3086235-Pseudomonas Infections,
pubmed-meshheading:3086235-Pseudomonas aeruginosa
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pubmed:year |
1986
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pubmed:articleTitle |
Lung defenses against Pseudomonas aeruginosa in C5-deficient mice with different genetic backgrounds.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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