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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1986-6-13
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pubmed:abstractText |
A B cell-specific monoclonal antibody (anti-Ba) was prepared. In two-color FACS analysis the anti-Ba reacted with a subpopulation of Ig+ or B1+ cells obtained from tonsils, but did not react with most B1+ cells derived from PBL. Activation of B cells from PBL with TPA or anti-mu induced Ba expression and the addition of PHA-conditioned supernatant with anti-mu-enhanced Ba expression. Other B cell activators, such as Staphylococcus aureus Cowan I (Staph-A) or PWM plus T cells, could induce Ba expression. Ba expression was observed 6 hr after stimulation and reached a peak level at 72 hr. Ba expression was strictly restricted to B cells. H-7, a specific inhibitor of protein kinase C (C-kinase), displayed a dose-dependent inhibitory effect on Ba expression, showing dependency on C-kinase for Ba expression. Anti-Ba inhibited B cell proliferation induced by anti-mu and B-BCGF distinct from BSF-1. The results presented in this study suggest that the Ba antigen on B cells may be comparable to the Tac antigen on T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, B-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
136
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4019-26
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3084651-Animals,
pubmed-meshheading:3084651-Antibodies, Monoclonal,
pubmed-meshheading:3084651-Antigen-Antibody Reactions,
pubmed-meshheading:3084651-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:3084651-Antigens, Surface,
pubmed-meshheading:3084651-B-Lymphocytes,
pubmed-meshheading:3084651-Binding, Competitive,
pubmed-meshheading:3084651-Enzyme Activation,
pubmed-meshheading:3084651-Female,
pubmed-meshheading:3084651-Growth Substances,
pubmed-meshheading:3084651-Humans,
pubmed-meshheading:3084651-Interleukin-4,
pubmed-meshheading:3084651-Lymphocyte Activation,
pubmed-meshheading:3084651-Lymphokines,
pubmed-meshheading:3084651-Mice,
pubmed-meshheading:3084651-Mice, Inbred BALB C,
pubmed-meshheading:3084651-Palatine Tonsil,
pubmed-meshheading:3084651-Phenotype,
pubmed-meshheading:3084651-Protein Kinase C,
pubmed-meshheading:3084651-Receptors, Antigen, B-Cell
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pubmed:year |
1986
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pubmed:articleTitle |
Expression and function of an early activation marker restricted to human B cells.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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