Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1986-6-2
pubmed:abstractText
Serum triglyceride and very low density lipoprotein (VLDL) concentrations were higher in male spontaneously hypertensive rat than in male control Wistar Kyoto rat, whereas serum cholesterol, phospholipids, and high density lipoprotein (HDL) concentrations were lower. Castration of hypertensive rats induced an increase in serum cholesterol, phospholipids, and HDL, and a decrease in serum triglyceride and VLDL. The cholesterol content of HDL increased, whereas the triglycerides decreased after gonadectomy of hypertensive rats. These changes in serum lipids and lipoproteins could be reversed by the administration of testosterone. Apolipoprotein E contents in VLDL and HDL of hypertensive rats were low when compared with control rats but rose after castration and could be reduced by testosterone administration. Hypertensive rats accumulated triglycerides and cholesterol in the liver, which resulted in an increase of liver weight. Castration reduced the hepatic lipids as well as liver weight. The effects of castration and testosterone treatment on lipids and lipoproteins were more prominent in spontaneously hypertensive rats than in control rats. These results suggest that testosterone reduces VLDL catabolism which is related to changes of apolipoprotein composition, and that hypertensive rats are more sensitive to testosterone than control rats.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins A, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins C, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, HDL, http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, LDL, http://linkedlifedata.com/resource/pubmed/chemical/Lipoproteins, VLDL, http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids, http://linkedlifedata.com/resource/pubmed/chemical/Testosterone, http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1787-94
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:3084207-Animals, pubmed-meshheading:3084207-Apolipoprotein A-I, pubmed-meshheading:3084207-Apolipoproteins, pubmed-meshheading:3084207-Apolipoproteins A, pubmed-meshheading:3084207-Apolipoproteins C, pubmed-meshheading:3084207-Apolipoproteins E, pubmed-meshheading:3084207-Cholesterol, pubmed-meshheading:3084207-Hypertension, pubmed-meshheading:3084207-Lipid Metabolism, pubmed-meshheading:3084207-Lipoproteins, pubmed-meshheading:3084207-Lipoproteins, HDL, pubmed-meshheading:3084207-Lipoproteins, LDL, pubmed-meshheading:3084207-Lipoproteins, VLDL, pubmed-meshheading:3084207-Liver, pubmed-meshheading:3084207-Male, pubmed-meshheading:3084207-Orchiectomy, pubmed-meshheading:3084207-Organ Size, pubmed-meshheading:3084207-Phospholipids, pubmed-meshheading:3084207-Rats, pubmed-meshheading:3084207-Rats, Inbred SHR, pubmed-meshheading:3084207-Rats, Inbred WKY, pubmed-meshheading:3084207-Testosterone, pubmed-meshheading:3084207-Triglycerides
pubmed:year
1986
pubmed:articleTitle
Effects of castration and testosterone administration on serum lipoproteins and their apoproteins in male spontaneously hypertensive rat.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't