| pubmed-article:3081578 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3081578 | lifeskim:mentions | umls-concept:C0085110 | lld:lifeskim |
| pubmed-article:3081578 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:3081578 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:3081578 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:3081578 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:3081578 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3081578 | pubmed:dateCreated | 1986-4-24 | lld:pubmed |
| pubmed-article:3081578 | pubmed:abstractText | A T cell surface membrane-associated glycoprotein, Tp40 (40,000 mol wt), also designated as CD-7, was not expressed by the T cells of a patient with severe combined immunodeficiency. In addition to this abnormality, T cell proliferative responses to mitogens were defective and the IL-2 receptor expression was deficient on the patient's T lymphocytes. However, his T cells were found to provide help for the differentiation of normal B cells to Ig-secreting cells. Abundant circulating B cells were detected. These B cells proliferated normally in the presence of anti-mu antibodies and B cell growth factors, but did not differentiate into antibody-secreting cells when provided with the help of normal T cells. In addition, his activated B cells did not proliferate to IL-2 even though IL-2 receptors were expressed. A successful allogeneic histocompatible bone marrow transplantation resulting in T cell engraftment corrected both the T and B cell immunodeficiencies. These findings support the hypothesis that the Tp40 deficiency present in this patient is related to a defect of the T cell precursors, and that Tp40 plays important roles not only essential to T cell interactions but also to certain aspects of T-B cell interaction during the early lymphoid development. | lld:pubmed |
| pubmed-article:3081578 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3081578 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3081578 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3081578 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:3081578 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:3081578 | pubmed:author | pubmed-author:GoodR ARA | lld:pubmed |
| pubmed-article:3081578 | pubmed:author | pubmed-author:HaraTT | lld:pubmed |
| pubmed-article:3081578 | pubmed:author | pubmed-author:KapoorNN | lld:pubmed |
| pubmed-article:3081578 | pubmed:author | pubmed-author:FuS MSM | lld:pubmed |
| pubmed-article:3081578 | pubmed:author | pubmed-author:JungL KLK | lld:pubmed |
| pubmed-article:3081578 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3081578 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:3081578 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3081578 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3081578 | pubmed:pagination | 940-6 | lld:pubmed |
| pubmed-article:3081578 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
| pubmed-article:3081578 | pubmed:meshHeading | pubmed-meshheading:3081578-... | lld:pubmed |
