Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1986-4-24
pubmed:abstractText
A T cell surface membrane-associated glycoprotein, Tp40 (40,000 mol wt), also designated as CD-7, was not expressed by the T cells of a patient with severe combined immunodeficiency. In addition to this abnormality, T cell proliferative responses to mitogens were defective and the IL-2 receptor expression was deficient on the patient's T lymphocytes. However, his T cells were found to provide help for the differentiation of normal B cells to Ig-secreting cells. Abundant circulating B cells were detected. These B cells proliferated normally in the presence of anti-mu antibodies and B cell growth factors, but did not differentiate into antibody-secreting cells when provided with the help of normal T cells. In addition, his activated B cells did not proliferate to IL-2 even though IL-2 receptors were expressed. A successful allogeneic histocompatible bone marrow transplantation resulting in T cell engraftment corrected both the T and B cell immunodeficiencies. These findings support the hypothesis that the Tp40 deficiency present in this patient is related to a defect of the T cell precursors, and that Tp40 plays important roles not only essential to T cell interactions but also to certain aspects of T-B cell interaction during the early lymphoid development.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-1097926, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-18618, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-310374, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-315518, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-3156928, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-316538, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-367653, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-378483, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-3920341, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-3926883, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6088664, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6092511, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6092512, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6118760, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6142255, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6196977, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6197113, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6222111, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6225849, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6228275, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6244678, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6278303, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6334716, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6354305, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6357489, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6418227, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6434689, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6447166, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6460785, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6499285, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6547160, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6606442, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6606451, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6609985, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6718115, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6771075, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6966197, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-6980917, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-7030922, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-7143170, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-7366657, http://linkedlifedata.com/resource/pubmed/commentcorrection/3081578-75233
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
940-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:3081578-Humans, pubmed-meshheading:3081578-Child, Preschool, pubmed-meshheading:3081578-Molecular Weight, pubmed-meshheading:3081578-Male, pubmed-meshheading:3081578-Glycoproteins, pubmed-meshheading:3081578-Bone Marrow Transplantation, pubmed-meshheading:3081578-Growth Substances, pubmed-meshheading:3081578-Membrane Proteins, pubmed-meshheading:3081578-Cell Differentiation, pubmed-meshheading:3081578-Immunologic Deficiency Syndromes, pubmed-meshheading:3081578-Antibody Formation, pubmed-meshheading:3081578-Lymphocyte Activation, pubmed-meshheading:3081578-Antigens, Surface, pubmed-meshheading:3081578-Lymphokines, pubmed-meshheading:3081578-T-Lymphocytes, pubmed-meshheading:3081578-B-Lymphocytes, pubmed-meshheading:3081578-Receptors, Immunologic, pubmed-meshheading:3081578-Antibodies, Monoclonal, pubmed-meshheading:3081578-Interleukin-2
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