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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1986-3-21
|
| pubmed:abstractText |
A gene was chemically synthesised and expressed in Escherichia coli to produce [Ala30,32,33]IFN-alpha 2, an analogue of human alpha 2-interferon (IFN-alpha 2) which is devoid of activity on human cells. Eight additional analogues provided single changes in IFN-alpha 2 at each of these three conserved positions. No one residue is essential for activity, but both antiviral and anti-proliferative activity are particularly sensitive to changes in the side-chain of Arg33.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
13
|
| pubmed:volume |
134
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1404-11
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3081003-Amino Acids,
pubmed-meshheading:3081003-DNA, Recombinant,
pubmed-meshheading:3081003-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:3081003-Escherichia coli,
pubmed-meshheading:3081003-Genes,
pubmed-meshheading:3081003-Humans,
pubmed-meshheading:3081003-Interferon-gamma,
pubmed-meshheading:3081003-Plasmids
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Functionally important conserved amino-acids in interferon-alpha 2 identified with analogues produced from synthetic genes.
|
| pubmed:publicationType |
Journal Article
|