| pubmed-article:3056740 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3056740 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:3056740 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:3056740 | lifeskim:mentions | umls-concept:C0025153 | lld:lifeskim |
| pubmed-article:3056740 | lifeskim:mentions | umls-concept:C0743284 | lld:lifeskim |
| pubmed-article:3056740 | lifeskim:mentions | umls-concept:C0032150 | lld:lifeskim |
| pubmed-article:3056740 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:3056740 | lifeskim:mentions | umls-concept:C0549178 | lld:lifeskim |
| pubmed-article:3056740 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:3056740 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3056740 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3056740 | pubmed:dateCreated | 1989-1-3 | lld:pubmed |
| pubmed-article:3056740 | pubmed:abstractText | A genetically homogeneous population of Plasmodium falciparum prepared by a single erythrocyte micromanipulation technique was used to produce lines of P. falciparum resistant to mefloquine hydrochloride in vitro. Parasites were maintained in a culture medium containing gradually increased concentrations of mefloquine hydrochloride (CMP-mef) starting with 2 ng/ml. One of the mefloquine-resistant culture lines (W2-mef) was obtained after 96 weeks of continuous culture in CMP-mef, the last 4 weeks in medium containing 40 ng/ml of mefloquine hydrochloride. The W2-mef was four to six times more resistant to mefloquine than was the parent clone W2. Means of multiple determinations of 50% inhibitory concentrations (IC-50) of mefloquine hydrochloride against W2-mef and clone W2 were 20.39 +/- 5.08 ng/ml and 4.50 +/- 1.94 ng/ml, respectively. | lld:pubmed |
| pubmed-article:3056740 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3056740 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3056740 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3056740 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3056740 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:3056740 | pubmed:issn | 0014-4894 | lld:pubmed |
| pubmed-article:3056740 | pubmed:author | pubmed-author:DesjardinsR... | lld:pubmed |
| pubmed-article:3056740 | pubmed:author | pubmed-author:WeatherlyN... | lld:pubmed |
| pubmed-article:3056740 | pubmed:author | pubmed-author:BowdreJ HJH | lld:pubmed |
| pubmed-article:3056740 | pubmed:author | pubmed-author:OduolaA MAM | lld:pubmed |
| pubmed-article:3056740 | pubmed:author | pubmed-author:MilhousW KWK | lld:pubmed |
| pubmed-article:3056740 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3056740 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:3056740 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3056740 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3056740 | pubmed:pagination | 354-60 | lld:pubmed |
| pubmed-article:3056740 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:3056740 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3056740 | pubmed:articleTitle | Plasmodium falciparum: induction of resistance to mefloquine in cloned strains by continuous drug exposure in vitro. | lld:pubmed |
| pubmed-article:3056740 | pubmed:affiliation | Department of Parasitology and Laboratory Practice, School of Public Health, University of North Carolina, Chapel Hill 27514. | lld:pubmed |
| pubmed-article:3056740 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3056740 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3056740 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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